Vyconil 25mg and 50mg

Vyconil contains clomipramine hydrochloride, a tricyclic agent that strongly blocks serotonin reuptake and, to a lesser degree, norepinephrine reuptake. By restoring serotonin signalling in brain circuits that govern mood, anxiety and intrusive thoughts, it gradually reduces obsessions, compulsions and associated distress. Benefits build over several weeks; sleep and anxiety often improve first, followed by intrusive thoughts and mood.

Therapy is individualized and usually follows a start-low, go-slow approach. Many adults begin with Vyconil-25 once daily, preferably in the evening if drowsiness occurs. If symptoms persist and the medicine is well tolerated, the dose may be increased to Vyconil-50, taken once daily or divided, as directed by the prescriber. Tablets should be swallowed whole with water. Do not stop suddenly; when discontinuation is appropriate, your doctor will guide a short taper. Lower doses are used in older adults and in people with liver problems.

Storage: Store the pack in a cool, dry place away from moisture and direct sunlight. Keep out of the reach of children.

Common side effects: Dry mouth, constipation, blurred vision, drowsiness, dizziness, sweating, tremor, nausea and weight gain may occur. Some people notice palpitations, postural light-headedness or sexual dysfunction. Most effects are mild and improve as the dose is adjusted. Seek medical help urgently for fainting, severe constipation or abdominal pain, confusion, fever with muscle stiffness, a seizure, eye pain with halos or any thoughts of self-harm.

Drug Warnings: Before starting Vyconil-25 or Vyconil-50, tell your doctor if you have glaucoma (especially narrow-angle), urinary retention or prostate enlargement, heart disease or a history of heart attack, arrhythmias, seizure disorders, bipolar disorder, thyroid disease, significant liver disease, or a history of low sodium. Use caution with activities requiring alertness until you know how the medicine affects you, and limit alcohol because it can increase drowsiness and impair judgment.

Drug–drug interactions: Do not combine clomipramine with MAO inhibitors; allow a 14-day washout when switching either way. Using it with other serotonergic medicines (SSRIs/SNRIs, linezolid or methylene blue, tramadol, lithium, St John’s wort) raises the risk of serotonin syndrome and needs close supervision. Caution is required with drugs that prolong the QT interval or lower the seizure threshold. Strong inhibitors or inducers of CYP2D6 or CYP1A2 (for example fluoxetine, paroxetine, bupropion, quinidine, ciprofloxacin, carbamazepine) can alter clomipramine levels; your clinician may adjust therapy. Combining with other anticholinergics increases dry mouth and constipation; with antihypertensives it may enhance postural dizziness.

Drug–food interactions: The tablets can be taken with or without food; a light meal may reduce stomach upset. Alcohol should be limited.

Drug–disease interactions: Extra care is needed in people with cardiac conduction problems, glaucoma, urinary retention, epilepsy, bipolar disorder, significant hepatic disease and in the elderly. Share your full medical history and medication list so your clinician can choose the most suitable strength and monitor treatment safely.