VATOIN 5mg, 10mg, 20mg

VATOIN (Vortioxetine Tablets) contains the multimodal antidepressant salt vortioxetine. Depression is linked to reduced serotonin activity in brain circuits that regulate mood, motivation, sleep and cognition. Vortioxetine blocks the serotonin transporter (SERT) to raise synaptic serotonin and also modulates several serotonin receptors (agonist/partial-agonist at some and antagonist at others), which together enhance downstream signaling. This combined action improves mood and anxiety symptoms and has been shown to help with cognitive difficulties of depression such as poor concentration and slowed thinking. The tablets are taken once daily and do not require meal timing. Early benefit may appear within one to two weeks, while full effect generally builds over four to six weeks.

Your doctor will select among the three strengths to suit your needs. Many adults start with VATOIN-5 or VATOIN-10 once daily; if well tolerated but symptoms persist, the dose may be increased to VATOIN-20 once daily, which is the usual maximum. Older adults or those sensitive to medicines may begin at 5 mg and titrate more slowly. Take your dose at the same time each day, with water. Do not stop suddenly unless your prescriber advises a taper, as a gradual reduction helps prevent discontinuation symptoms such as dizziness, irritability and sleep disturbance.

Storage: Store VATOIN in a cool, dry place away from moisture and direct sunlight. Keep the pack tightly closed and out of the reach of children.

Common Side Effects: The most frequent effect is nausea, usually mild and transient. Some people notice constipation or loose stools, vomiting, abdominal discomfort, dizziness, headache, dry mouth, abnormal dreams, sleepiness or insomnia, and occasionally itching or sexual dysfunction. Appetite or weight typically change little. Seek medical help promptly for signs of serotonin syndrome (fever, sweating, agitation, tremor), unusual bruising or bleeding, severe rash, eye pain with vision changes, or any thoughts of self-harm.

Drug Warnings: Before taking VATOIN (vortioxetine), inform your doctor if you have bipolar disorder or a history of mania/hypomania, seizures, glaucoma (especially narrow-angle), liver or kidney problems, low sodium or use of diuretics, bleeding disorders or use of blood thinners, heart-rhythm issues, or if you are pregnant, planning pregnancy or breastfeeding. Avoid taking this medicine with other sedating medications unless advised, as it may increase drowsiness.

Drug–Drug Interactions: Do not use with MAO inhibitors (including linezolid or methylene blue) or within 14 days of stopping one. Use with other serotonergic medicines—such as SSRIs/SNRIs, triptans, tramadol, lithium or St John’s wort—raises the risk of serotonin syndrome and requires medical supervision. Strong CYP2D6 inhibitors (for example bupropion, fluoxetine, paroxetine, quinidine) can increase vortioxetine levels; your prescriber may use the lower dose. Strong CYP inducers (such as rifampicin, carbamazepine, phenytoin, St John’s wort) can reduce effect; dose adjustments or alternatives may be considered. Vortioxetine may increase bleeding tendency when combined with aspirin, NSAIDs or anticoagulants. Always tell your doctor about all prescription, over-the-counter and herbal products you take.

Drug–Food Interactions: VATOIN can be taken with or without food. Alcohol should be limited, as it can worsen dizziness, judgment and reaction time.

Drug–Disease Interactions: Caution is advised in patients with bipolar disorder, seizure disorders, hyponatremia/SIADH risk, glaucoma, bleeding diathesis, and in those with hepatic or renal impairment who may need closer monitoring. Always share your full medical history to ensure the safe and effective use of VATOIN 5 mg, 10 mg and 20 mg (vortioxetine).